Quick saves might be fine- but in this or any game- I might use both or just the hard save- press esc then save. It is even written in the fo3 tweak guide it can be glitcy and is best to make multi saves or the most safe is always the hard save- Esc then save.
Also in fo games or I have seen in nv is you can lose stuff- or your companions can lose stuff. Spawning through doors and going to other parts of the map or the casinos they take your weapons- when you leve they give them back- sometimes you do not get it all back or your companions might not get something back. Any special weapons you find like easter eggs etc- I do not give them to my companions- they might lose them. I only give them what I want and can stand to lose- but is all good stuff and fully repaired etc. But maybe if going certain places you lower all your gear over all the groups inventory so less chance to bug and lose stuff- you can always go back and forth to your main base or house etc.
It is a good idea anytime you have to re spawn anyplace- check all of your groups inventory- the less stuff less to look at or miss- you get the idea.. It is good to save before you go to re spawn any place or through doors etc. So you see something missing just go back to the last save and do it again or just leave and go home and drop off some stuff in a safe place- then go back.. Just know is all..
It is best to hard save in all of your games it is more safe- or for games that have saves and not check points..


















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